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Pharmaceutical preparations for use in the treatment of gynecological disorders and conditions, namely, gynecological disorders conditions affecting nervousness, depression, mood, anxiety, and cognitive function, perspiration, headache, palpitation, sleep, and bone and joint pain; pharmaceutical preparations for use in the treatment of sexual dysfunction; pharmaceutical preparations and substances for the treatment of hormonal related diseases, disorders, and deficiencies; pharmaceutical preparations for use in the treatment of neurological diseases and disorders, psychiatric diseases and disorders, psychological diseases and disorders, cognitive impairment disorders, sleep disorders, panic disorders and anxiety disorders; pharmaceutical preparations and substances for use in the treatment, alleviation and prevention of thermoregulatory dysfunctions and vasomotor symptoms including hot flashes, hot flushes, night awakenings, night sweats, and such disorders and conditions associated with perimenopause, menopause and hormonal deficiencies