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Non-wearable, wearable and implantable medical devices and apparatus related to the selective manipulation and removal of blood factors for manipulation of the immune system in the extra-corporeal blood treatment of targeted diseases and for therapeutic blood treatment, consisting of apheresis devices for blood cell collection, plasma and cell separation, and retransfusion of blood from which some constituents have been removed, and accessories thereof, namely, irradiators, blood mixers, blood filters, immunoadsorbents, resins, blood pumps, blood containers and disposable goods for blood collection and treatment, namely, blood tubing sets, blood collection bags, blood storage bags, blood collection bag sets and blood filters for use in blood collection bags, all sold together as a unit